Tumour microenvironment profiling and pathway enrichements

Independent analysis of publicly available scRNA-seq data

Objective
Characterise transcriptional heterogeneity and biological programmes across the mesothelioma tumour microenvironment in context to oncogenic programmes and immune components of the tumour microenvironment (TME).

‍Approach
Single-cell processing and annotation, UCell signature scoring, patient-level comparisons, pathway analysis and visualisation

.Example analysis
[EMT UCell UMAP]
‍
Example of cell-level epithelial–mesenchymal transition activity.

‍Methods
R · Seurat · UCell · pathway analysis ‍Data source
Giotti et al., Cancer Discovery (2024), GSE190597.

‍Need a similar analysis?

Discuss your project