CBC LABS
BIOINFORMATICS SERVICES
Bioinformatics and computational solutions across transcriptomics, single-cell analysis, biomarker discovery and causal modelling.
SINGLE-CELL ANALYSIS
Single-cell transcriptomic analysis to characterise tumour and immune populations and identify cell-type-specific molecular programmes and pathway activity.
scRNA-seq · Seurat · Pathway analysis · UCell · Giotti et al 2024
RNA-seq transcriptomic analysis
Bulk RNA-seq analysis addressing broader and general transcriptomic questions, including differential expression, gene set enrichemnt analysis (GSEA) , trasncription factor and gene ontology.
RNA-seq · DEseq2 · GSEA · Decoupler · ssGSEA · Transcription factor analysis · In-house data
CAUSAL INFERENCE - ADVANCED ANALYTICS
Causal modelling integrating structural equation modelling, Bayesian networks and causal inference to investigate potential biological mechanisms in silico.
bnlearn · laavan · do-calculus · DoWhy · TCGA
Tool & Pipeline Development
Custom bioinformatics and computational pipelines designed to automate reproducible analyses and streamline complex research workflows.
BASH · R · Python
BIOMARKER DISCOVERY · PREDICTIVE MODELLING
Development and evaluation of predictive biomarkers using molecular and microbiome data, including model optimisation, performance assessment and ROC-based validation.
Biomarkers · ROC/AUC · Predictive modelling · Statistical validation · Zhang et. al. 2024
RESEARCH STRATEGY - Study design
Bioinformatics-led study design built around the research question, available data and analytical objectives, with a focus on robust and reproducible downstream analysis.
Study design · Cohort planning · Statistical strategy · Multi-omics